TMBC Monthly Newsletter, August 2017, V9
Every month The Microbiome Coalition (TMBC) will bring you the latest in research, news and information to keep you up to date on the microbiome industry. We welcome your feedback and suggestions for content.
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Microbiome in the Spotlight
Simple Changes, Enormous Benefits
Not all disease has to be treated with expensive, hard to develop pharmaceuticals - although the industry may not want you to believe that. If the present body of research on the microbiome has shown us nothing else, there are serious and potentially deadly consequences from minor changes in the composition of the microbiome. But do we always need pharmaceuticals to redress these issues?
Apparently not. A research team at the University of Nebraska Medical Center College of Public Health, led by Professor Pinaki Panigrahi, M.D., Ph.D., and funded by NIH, has demonstrated that a simple mixture of good bacteria can reduce the incidence of sepsis in infants in India by 40 percent.
At a cost of $1 per infant.
Read more here
In Business News
Fitbiomics Launching to Offer Microbiome Based on Athletic Ability
George Church's lab first asked the question of whether athletes have a specific microbiome that could assist other athletes in increasing performance. They started their work by collecting fecal samples on a daily basis from 20 athletes training for the 2015 Boston marathon, one week before and one week after the race. What they found was a post-race spike in one bacteria that breaks down lactic acid. They are also comparing samples between sports - rowing and ultra running - to identify bacterial differences that support different sports. And hoping to launch a company next year to offer a novel sports specific probiotic. Full article here
CoreBiome Receives Seed Funding to Offer Microbial Analysis
CoreBiome is based on patent-pending genomic technology and informatics tools developed at the University of Minnesota that allow for an unprecedented level of control, reproducibility and accuracy in providing detailed information about microbial communities. Full article here
Matrisys Bioscience Phase 2A Study
The first patient has been dosed in a Phase 2A clinical study of an investigational commensal lotion based preparation of “universal” live biologic therapeutic Staphylococcus hominis strain in adults with moderate-to-severe atopic dermatitis. Full article here
In Research News
The Role of Microbiome Dysbiosis in Gynecological Carcinogenesis
It is already known that a well-balanced microbiome in the vaginal region is pivotal in preventing infections of the genital tract; however, recent evidence shows it may even influence the development of malignant changes in the cervix and other constituents of the genital tract. Full article here
More Evidence of the Gut-Brain Connection
Next-generation sequencing studies by Alan E. Hoban, Ph.D. and colleagues at the the APC Microbiome Institute at University College Cork showed that germ-free mice that are born with no gut microbiota demonstrated altered expression of 103 miRNAs in the amygdala and 31 in the prefrontal cortex regions of the brain, which are areas known to be involved in anxiety and depression. A number of the miRNAs identified have previously been linked with stress and fear responses in mice. Full article here
And Some Evidence of the Brain Gut Connection . . . It Goes Both Ways?
Oregon State University researchers found that when someone is under stress, their gut microbiome communities become discombobulated and behave erratically, in ways that are unpredictable and vary from person to person. Full article here
IBM Getting Into the Microbiome Game . . . With the Broad Institute, MIT and others.
IBM is hoping to shed some light on the role of the microbiome in autoimmune diseases using crowdsourced supercomputers through its World Community Grid in partnership with the Broad Institute, MIT, Massachusetts General Hospital, University of California San Diego, and the Simons Foundation’s Flatiron Institute. Read more here
Watching This Week . . .
TED Talk, Professor Jessica Green, University of Oregon, on the microbiome of the built environment and considering it more purposefully. Watch here
Assistant Marketing Intern, The Microbiome Coalition (TMBC)
The Microbiome Coalition (TMBC) is a newly launched coalition of commercial companies that seek to promote greater public understanding of the role of the microbiome in human health and wellness, and works to advance appropriate regulation, needed investment and required infrastructure. TMBC is seeking an Assistant Marketing Intern to play a crucial role in developing and growing the visibility and size of the organization. This internship will give you real marketing experience. If interested, get in touch here
Albert Einstein College of Medicine, PostDoc in Microbiome Research
The Mani Laboratory, housed in The Albert Einstein College of Medicine, INC (SEE website: https://sites.google.com/view/mani-lab) has an open position for a highly motivated postdoctoral fellow. These studies will include delving into the mechanisms of host-microbe (and microbe-host) interactions and study of the mechanisms of bacterial biofilms using both genetic, biochemical and biophysical approaches. Learn more here
Assistant Professor, Human Microbiome Science, University of Oregon
Department of Biology Invites applications for a tenure-related position (Assistant Professor) in Human Microbiome Science. We are particularly interested in candidates whose research focuses on innovative computational, molecular, and/or microbiological approaches to address fundamental questions regarding the assembly, dynamics and function of the human microbiome. Learn more here
Microbiome: Translating into Diagnostics and BioTherapeutics Summit
The Summit will shed light on current challenges, best practices, and the inside view of the future of Microbiome in relation to precision medicine, Sept 21-22, Vienna, Austria, http://vonlanthengroup.com
Microbiome in Immune Oncology
Understanding the relationship between the human microbiome and cancer could be instrumental in transforming immune-modulating therapies, since a certain immunotherapy is reliant on the gut’s microflora, Sept 25, Boston, MA, http://www.discoveryontarget.com
5th Microbiome R&D & Business Collaboration Forum
This two-day, interactive meeting, will provide the opportunity to examine the latest research into microbial communities with a focus on translation to therapeutics. San Diego, Nov 2-3, http://www.global-engage.com/event/microbiome/
Keystone Symposia, Microbiome in Health and Disease
This Keystone Symposia meeting brings together experts in clinical medicine, clinical microbiology, microbial genomics, and bacterial genetics to explore how both strain variation and underlying microbial community determine health and disease. Keystone, CO, Feb 5-9, http://www.keystonesymposia.org
Microbiome Awards, Fellowships and Prizes
University of Buffalo's Community of Excellence in Genome, Environment and Microbiome (GEM) Awards Four studies focused on improving our understanding of the human genome and microbiome were awarded funding through the third round of research pilots at GEM. Learn more about the work these four researchers are doing here
Consider joining the coalition. Members of TMBC participate on our committees, attend our events, generate networking and business development opportunities and, most importantly, contribute to the growth and success of a unique organization that is positioned to ensure that public opinion and policy pave the way for microbiome based therapeutics, diagnostics and direct-to-consumer services and products.
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