TMBC Monthly Newsletter, August 2017, V9

Every month The Microbiome Coalition (TMBC) will bring you the latest in research, news and information to keep you up to date on the microbiome industry. We welcome your feedback and suggestions for content.

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Microbiome in the Spotlight

While the body of research of the impact and involvement of the human microbiome on health and disease continues, we should also consider how the human microbiome interacts with
our environmental microbiome.

Jack Gilbert, PhD, Director of the Microbiome Center and Professor of Surgery at the University of Chicago recently com pleted a 12-m month study mapping bacterial diversity within a hospital—with a focus on the flow of microbes between patients, staff and surfaces. The Hospital Microbiom e Project is the single biggest m icrobiom e analysis of a hospital performed and provides valuable insights into how the human microbiome interacts with the environmental microbiome. Full article here

In Business News

Skin Biotherapeutics: New Company in the Emerging Field of the Skin Microbiome

Spun out of OptiBiotix last month, SkinBioTherapeutics PLC is focused on the skin microbiome and led by chief executive Dr Cath O’Neill and her team at Manchester University. As part of the separate listing the company raised £4.5mln, which will be invested in developing a cosmetic for sensitive skin, an anti-infective hand product and potential treatment for eczema. Full article here

Professor Borody Calls for a National Australian FMT Bank to Fight Drug Resistant Diseases

Faecal Microbiota Transplantation (FMT) leader Professor Thomas Borody has called for a national faecal bank to fight drug resistant and epidemic diseases in hospitals and clinics across the country. Professor Borody, the Founder and Medical Director of the Centre for Digestive Diseases (CDD) in Sydney, was the first in Australia to perform FMT, and he set up the world's first faecal bank in 1988. Full text here

ATCC and One Codex Form Partnership to Address Microbiome Research Needs.

Two of the key challenges in microbiome research, identified by the National Institute of Standards and Technology (NIST) and opinion leaders in the field, are genom ic sequencing data reproducibility and comparative standards. The ATCC Microbiome Research Solutions portfolio, launched in partnership with One Codex, will provide sequencing controls and reference materials addressing these issues. Full text here

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In Research News

The Fungal Microbiome Contributes to Alcohol-Induced Liver Damage in Mice.

A study led by Bernd Schnabl connects alcohol-driven changes in the fungal microbiome to liver disease. The research team at the University of California San Diego discovered that chronic alcohol intake increased fungal populations in the intestine as well as levels of the fungal structural molecule β-glucan in the bloodstream of mice. Full article here

Circadian Clocks Influence Body’s Response to Diet

Scientists from Baylor College of Medicine have found that alterations to the circadian clock affect how the body responds to diet. In turn this influences microbes residing in the digestive tract. The research showed how the circadian clock, the internal mechanism that helps orchestrate body activities such as going to sleep or when to eat, and the microbiome interact and when these go out of synchronicity this can affect metabolism , in particular how we metabolize our food. Full article here

Obesity Surgery May Work by Remaking Your Gut Microbiome

It turns out gastric bypass not only restructures the topology of the hum an gut, but profoundly changes which microbes can survive and thrive in it. In a National Institute of Health-backed study published today, researchers at Arizona State University showed that patients who underwent the procedure developed totally different m icrobiom es, replete with organism s that prom oted weight loss. And the effect appears to be permanent. The results confirm ed earlier research with a sm aller sam ple size, and also com pared gastric bypass with another popular, though less invasive bariatric surgery. Only the bypass impacted microbiome diversity. Full article here

Study Suggests Diabetic Obese Children Prone to Poor Oral Health

Published March 2 in PLOS One, the study of three groups of children — 19 normal-weight children, 14 obese children and 16 obese children with Type 2 diabetes — found that poor oral health is more common in obese children with type 2 diabetes. “We found a trend toward more periodontal disease in obese children with Type 2 diabetes,” says senior author Lucy D. Mastrandrea, MD, PhD, associate professor of pediatrics. Full article here

Gut Microbiome May Predict Response to Biologic Therapy for Inflammatory Bowel Disease

Analysis of a patient's gut microbiome may be able to predict the likelihood of successful treatment for inflammatory bowel disease (IBD) with biologic drugs that target immune system activity. In their report published in Cell Host and Microbe, researchers from Massachusetts General Hospital, the Broad Institute and Harvard describe differences in both the com position and the function of the gut m icrobiom e between patients for whom treatment with a monclonal antibody-based drug was and was not effective in inducing rem ission of IBD sym ptom s. Full article here

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In Member News

CosmosID, Inc. Announces Metagenomics Presentations in Clinical Diagnostics and Global "Healthy" Gut Microbiome at ASM Microbe 2017

CosmosID, Inc., a biotechnology com pany focused on im proving life and wellness through unlocking potential of the m icrobiom e, announced new findings of research studies em ploying its highly curated genome database and next-generation sequencing analysis platform at the American Society for Microbiology Microbe 2017 conference, at the Ernest N. Morial Convention Center June 1 – 5 in New Orleans. Press release here 

Job Board

Assistant Marketing Intern, The Microbiome Coalition (TMBC)

The Microbiome Coalition (TMBC) is a newly launched coalition of com m ercialcom panies that seek to promote greater public understanding of the role of them icrobiom e in hum an health and wellness, and works to advance appropriateregulation, needed investment and required infrastructure. TMBC is seeking an Assistant Marketing Intern to play a crucial role in developingand growing the visibility and size of the organization. This internship will give you realmarketing experience. If interested, contact 

Lab Director, Second Genome, South San Francisco, CA

Second Genome is expanding its genomics laboratory facility for conducting m icrobiom e research. We are looking for an experienced lab director with background in NGS and other genom ic technologies to lead the expansion of the services laboratory including acquisition of new equipment and staffing of new personnel. Learn more here

Microbiome Research Scientist (BS or MS), NIBRI, Cambridge, MA

NIBR is seeking an innovative scientist to join a drug discovery program in the area of human microbiome research. The successful candidate will work in a dynam ic new discovery departm ent nam ed Chem ical Biology and Therapeutics (CBT) that aspires to discover and create new types of sm all m olecules- and
biom olecules- to identify new targets, to dissect hum an biology and address key unm et m edical needs associated with dysregulation of the microbiome. She/he will be part of a team that works at the interface of the human microbiome, human disease and novel metabolite activity testing for elucidating metabolite mechanism of action in the context of mucosal immunology. Learn more here

Assoc Professor/Professor, NHM (Microbiome), The University of Alabama, Tuscaloosa, AL

The Departm ent of Hum an Nutrition and Hospitality Managem ent at The University of Alabam a seeks applications from individuals with an interest and expertise in the role of nutrition in microbiome-host physiological interactions and/or the role of m etals on gut m icrobiom e and hum an health for hire at the Associate Professor or Full Professor rank. This position will be part of a cluster of positions in conjunction with the Departm ents of Chem istry and Biology at the University of Alabam a; start-ups will be highly competitive. Learn more here

Upcoming Conferences

IPA World Congress + Probiota Amercias 2017, June 7-9, San Francisco, CA

The IPA World Congress + Probiota Americas 2017 in San Francisco, June 7-9, explores the probiotic scientific frontier, its evolution and com m ercial application in food, supplem ents and related product areas. Conference website here

Microbiome Discovery and Development Congress 2017, June 12-13, Berlin, Germany

Oxford Global is proud to present the inaugural Microbiome Discovery and Development Congress on the 12 – 13 June 2017 in Berlin, Germany. This congress will bring together key opinion leaders and senior industry experts in microbiome drug discovery to discuss the latest innovative discovery strategies and technologies, the commercialization of the microbiome and the therapeutic potential. Conference website here

Microbiome Drug Development Summit, June 27-29, Boston, MA

Being part of Microbiom e Drug Developm ent Sum m it gives you the opportunity to get unprecedented access to the latest preclinical, clinical and com m ercial case studies from the brightest m inds in biopharm a and academia to turn microbiome discoveries of today into patient therapies of the future. Conference website here 

Microbiome Awards, Fellowships and Prizes

Harvard Chan School Awarded $4.9 Million toCreate Microbiome Biobank

Harvard Chan School received $4.9 m illion from the Massachusetts Life Sciences Centerto launch Biobank for Microbiome Research in Massachusetts (BIOM-Mass) in collaboration with the Brigham and Women’s Hospital (BWH) and Massachusetts General Hospital (MGH). The award is part of $18 million in capital infrastructure grants given by the Massachusetts Life Sciences Center to research institutions in Boston. These awards were highlighted at a ceremony at Harvard Medical School on May 15, 2017. Full press release here 

$100 Million Gift Establishes the Duchossois Family Institute at the University of Chicago Medicine
A Chicago-area fam ily with a deep commitment to supporting science and m edicine is giving $100 m illion to establish The Duchossois Family Institute at the University of Chicago Medicine, which seeks to accelerate research and interventions based on how the hum an im m une system , m icrobiom e and genetics interact to maintain health. The gift from The Duchossois Group Inc. Chairman and CEO Craig Duchossois, his wife, Janet Duchossois, and The Duchossois Family Foundation will support development of a “new science of wellness” aimed at preserving health and complementing medicine’s traditional focus on disease treatment. Full press release here 

TMBC Membership

Consider joining the coalition. Mem bers of TMBC participate on our com m ittees, attend our events, generate networking and business development opportunities and, most importantly, contribute to the growth and success of a unique organization that is positioned to ensure that public opinion and policy pave the way for microbiome based therapeutics, diagnostics and direct-to-consumer services and products.

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• Sole proprietor (legal, consulting, other) • Academ ic and clinical institutions • Patient advocacy groups • Industry/trade associations
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Benefits of Membership

• Shape the Future of Microbiome Policy • Curated research library
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